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Grade: A In adults with type 2 diabetes, glucose-lowering agents may be continued upon initiation of insulin therapy (unless contraindicated or not tolerated) for ongoing glycaemic and metabolic benefits (ie weight, cardiometabolic or kidney benefits)

Rodrigues VF, Elias-Oliveira J, Pereira S, et al

However, it is unclear which of these, the size increase or HSA binding, are more pharmacologically relevant and account for the observed extension of the half-life

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